A Vitamin A derivative, ReFissa ™ reduces fine lines and wrinkles, smooths texture and brightens the skin utilizing a new formulation of tretinoin. ReFissa™ is the only FDA approved prescription cream with a strength of .05%, that’s fragrance-free, moisturizing to the skin and is clinically proven to be effective. In clinical trials, 71% of women saw an improvement in the minimizing of facial wrinkles, and 83% saw an improvement in the brightening of their skin.